regioneReloaded

regioneReloaded enables simultaneous analysis of associations between genomic region sets, supporting data clustering and direct comparison of statistical results across multiple analyses.

Key Features:

• Multiple association analysis: Analyzes associations between multiple genomic region sets simultaneously.
• Clustering: Enables clustering of data from multiple region set comparisons.
• Publication-ready visualization: Provides plotting functions for generating ready-to-publish graphs.
• Improved p-value calculation: Incorporates a strategy to improve p-value calculations.
• Z-score normalization: Normalizes z-scores from multiple analyses to allow for their direct comparison.
• regioneR compatibility: Takes over and expands on all features of its predecessor regioneR.

Scientific Applications:

• Genomic region set comparison: Compares associations across multiple genomic region sets in a single analysis framework.
• Cross-analysis statistical integration: Enables direct comparison of statistical results from multiple independent analyses through normalized z-scores.
• Functional genomics visualization: Generates publication-ready graphical outputs for genomic region association studies.

Methodology:

The package implements a strategy to improve p-value calculations and normalizes z-scores coming from multiple analyses to allow for their direct comparison.