roastgsa

roastgsa implements gene set analysis functions using rotations to approximate the null distribution and provides seven test statistic scores for varied analytical goals and interpretations.

Key Features:

• Rotation-based null approximation: Uses rotations to approximate the null distribution for gene set analysis.
• Multiple test statistics: Implements seven test statistic scores that can be used with different goals and interpretations.
• Graphical representations: Provides several functions to complement statistical results with graphical representations.

Scientific Applications:

• Gene set analysis: Enables statistical testing of predefined gene sets for differential expression or other coordinated changes.

Methodology:

Rotation-based approach to approximate the null distribution for gene set analysis, with seven implemented test statistic scores.