rrvgo

rrvgo reduces and visualizes lists of Gene Ontology terms by identifying redundancy based on semantic similarity.

Key Features:

• Redundancy reduction: Groups similar Gene Ontology terms based on their semantic similarity to simplify interpretation of large GO lists.
• Visualization options: Provides multiple visualization methods to guide interpretation of summarized Gene Ontology terms.
• Up-to-date annotations: Leverages current Gene Ontology gene annotation provided by the Bioconductor project.

Scientific Applications:

• Omics data interpretation: Facilitates biological interpretation of high-throughput omics experiments by simplifying redundant lists of enriched Gene Ontology terms from differentially regulated gene analyses.

Methodology:

Calculates semantic similarity between Gene Ontology terms to identify redundancy and group similar terms.