satuRn

satuRn provides a highly performant and scalable framework for performing differential transcript usage analyses.

Key Features:

• fitDTU: Fits quasi-binomial generalized linear models that model transcript usage in different groups of interest.
• testDTU: Tests for differential usage of transcripts between groups of interest.
• plotDTU: Visualizes the usage profiles of transcripts in groups of interest.
• Scalability: Supports both bulk and single-cell RNA-sequencing applications.

Scientific Applications:

• Differential transcript usage analysis: Identifies changes in transcript usage patterns between experimental conditions in bulk and single-cell RNA-sequencing data.

Methodology:

satuRn fits quasi-binomial generalized linear models to model transcript usage, followed by statistical testing for differential transcript usage between groups.