SCBN

SCBN implements a scale-based normalization method to identify differentially expressed genes between different species using RNA-seq data.

Key Features:

• Cross-species normalization: Provides scale-based normalization specifically for RNA-seq data from different species.
• Orthologous gene integration: Incorporates available knowledge of conserved orthologous genes into the normalization framework.
• Differential expression detection: Applies a hypothesis testing framework to detect differentially expressed orthologous genes.

Scientific Applications:

• Comparative transcriptomics: Enables differential expression analysis of RNA-seq data across different species.
• Orthologous gene analysis: Identifies differentially expressed orthologous genes between species using conserved gene sets.

Methodology:

Scale-based normalization using conserved orthologous genes with hypothesis testing for differential expression.