scConform

scConform builds prediction intervals for cell type annotation using conformal inference and conformal risk control.

Key Features:

• Standard Conformal Inference: Provides prediction intervals with coverage guarantees based on standard conformal inference.
• Hierarchical Conformal Inference: Provides hierarchical prediction intervals that are consistent with the cell ontology.

Scientific Applications:

• Cell Type Annotation: Generates prediction intervals with statistical coverage guarantees for assigning cell types in single-cell data.
• Ontology-Consistent Annotation: Produces hierarchical prediction intervals that maintain consistency with the cell ontology structure.

Methodology:

scConform implements two main methods: standard conformal inference for prediction intervals with coverage guarantees, and hierarchical prediction intervals based on conformal risk control that are consistent with the cell ontology.