scMitoMut

scMitoMut calls lineage-informative mitochondrial mutations from single-cell sequencing data such as scRNASeq and scATACSeq.

Key Features:

• Mutation Calling: Mutation calling is performed using beta-binomial distribution.
• Visualization: The package includes functions for visualizing mutation results.

Scientific Applications:

• Lineage Tracing: Identification of lineage-informative mitochondrial mutations enables cell lineage reconstruction from single-cell data.
• Single-cell Genomics: Analysis of mitochondrial DNA variation in scATACSeq and scRNASeq datasets, with preference for scATACSeq due to RNA editing issues.

Methodology:

Mutation calling is done using beta-binomial distribution.