ScreenR

ScreenR performs hit identification in loss of function High Throughput Biological Screenings using barcoded shRNA-based libraries by executing a pipeline that finds candidate hits from barcode counts.

Key Features:

• Hit identification pipeline: ScreenR executes a pipeline able to find candidate hits from barcode counts.
• Integration with edgeR: ScreenR combines the computing power of edgeR for statistical analysis.
• Tidyverse integration: ScreenR integrates with the Tidyverse metapackage for data manipulation workflows.
• Visualization modes: ScreenR integrates a wide range of visualization modes for each step of the analysis.

Scientific Applications:

• Loss of function screening: ScreenR supports hit identification in loss of function High Throughput Biological Screenings performed using barcoded shRNA-based libraries.

Methodology:

ScreenR executes a pipeline that finds candidate hits from barcode counts, combining edgeR for statistical computing with Tidyverse for data manipulation.