SMAD

SMAD assigns probability scores to protein interactions captured in affinity purification mass spectrometry (AP-MS) experiments to infer protein-protein interactions and facilitate non-specific background removal of contaminants.

Key Features:

• Probability Score Assignment: Assigns probability scores to protein interactions captured in AP-MS experiments.
• Background Removal: Facilitates non-specific background removal by identifying contaminants commonly found in AP-MS data.

Scientific Applications:

• Protein-Protein Interaction Inference: Infers protein-protein interactions from AP-MS experimental data.
• Contaminant Filtering: Enables removal of non-specific contaminants from AP-MS datasets.

Methodology:

Statistical modelling of AP-MS data to assign probability scores to protein interactions.