SMTrackR

SMTrackR maps protein-DNA binding on individual sequenced DNA molecules using exogenous enzyme imprinted information.

Key Features:

• Enzyme-based protein-DNA binding mapping: The package utilizes imprinting information from exogenous enzymes including GpC methyltransferase, CpG methyltransferase, and Adenine methyltransferases to map protein-DNA interactions.
• Single-molecule resolution: The package maps protein-DNA binding on individual sequenced DNA molecules rather than population averages.
• Compiled public datasets: Public datasets from enzyme imprinting assays are compiled into tracks for analysis.

Scientific Applications:

• Protein-DNA interaction mapping: The package enables mapping of protein binding locations on individual DNA molecules using enzymatic imprinting data.
• Chromatin accessibility analysis: The package supports analysis of individual DNA molecule accessibility patterns through exogenous enzyme imprinting.

Methodology:

The package accesses compiled public datasets hosted at public servers such as Galaxy.