sosta

sosta analyzes spatial omics data to explore tissue organization at the anatomical structure level.

Key Features:

• Anatomical structure reconstruction: Reconstructs anatomically relevant structures based on molecular features or cell types.
• Structure-level metrics: Calculates a range of metrics at the structure level to quantitatively describe tissue architecture.
• Package integration: Integrates with other packages for the analysis of spatial omics data.

Scientific Applications:

• Multicellular anatomical structure analysis: Enables direct analysis of multicellular, anatomical structures from spatial omics data, moving beyond single-cell spatial arrangement analysis.
• Tissue architecture quantification: Quantitatively describes tissue architecture through structure-level metrics in high-resolution, large-scale spatial omics datasets.

Methodology:

The package implements structure-based analysis of spatial omics data, focusing on direct analysis of multicellular, anatomical structures rather than single-cell spatial arrangements.