spatialFDA

spatialFDA calculates spatial statistics metrics and compares them across samples or conditions using functional additive models.

Key Features:

• Spatial Statistics Calculation: The package takes a SpatialExperiment object and calculates spatial statistics metrics using the package spatstat.
• Cross-sample Comparison: It compares the resulting functions across samples/conditions using functional additive models as implemented in the package refund.
• Exploratory Visualization: It provides exploratory visualisations using functional principal component analysis, as implemented in refund.

Scientific Applications:

• Spatial Multi-sample Comparisons: Enables comparison of spatial statistics across multiple samples or experimental conditions in spatial transcriptomics or other spatial omics data.

Methodology:

The package uses spatstat to calculate spatial statistics metrics from SpatialExperiment objects, then applies functional additive models from refund for cross-sample comparisons, and functional principal component analysis from refund for exploratory visualization.