SynMut

SynMut designs synonymously mutated DNA sequences with different genomic signatures by accounting for dinucleotide preference and/or codon usage bias.

Key Features:

• Dinucleotide preference incorporation: Designs mutants with specified dinucleotide composition patterns.
• Codon usage bias incorporation: Designs mutants with specified codon usage patterns.
• Combined design capability: Simultaneously accounts for both dinucleotide preference and codon usage bias during mutant design.
• In silico mutant design: Enables computational generation of DNA sequence mutants without experimental intervention.

Scientific Applications:

• Virus mutant design: Generates synonymously mutated viral sequences with altered genomic signatures for research purposes.
• Genomic signature engineering: Creates sequences with distinct dinucleotide or codon composition profiles.

Methodology:

Synonymous mutation design incorporating dinucleotide preference and/or codon usage bias for in silico DNA sequence mutant generation.