terapadog

terapadog performs Gene Set Analysis using the PADOG approach on genes reported as translationally regulated by the DeltaTE package to assess the impact of translational efficiency changes on gene sets.

Key Features:

• PADOG-based Gene Set Analysis: Applies the PADOG method specifically to translationally regulated genes identified by DeltaTE.
• Integration with ReactomeGSA: Functions as an additional analysis method within ReactomeGSA for pathway-level contextualization including directionality of change.

Scientific Applications:

• Translational Regulation Impact Assessment: Evaluates how translational efficiency changes affect functional gene sets and pathways.
• Pathway Contextualization: Provides biological interpretation of translational regulation results through ReactomeGSA integration with pathway and directionality information.

Methodology:

The package uses the PADOG approach for Gene Set Analysis applied to genes exhibiting significant changes in translational efficiency as determined by the DeltaTE package.