uncoverappLib

uncoverappLib provides a suite of graphical and statistical tools to support clinical assessment of low coverage regions at the base-pair level.

Key Features:

• Coverage Analysis Module: Provides statistical summary of coverage given a target file or gene names.
• Allele Frequency Calculation Module: Calculates allele frequency (AF) by allele frequency.
• Binomial Distribution Module: Provides binomial distribution analysis as a separate analytical module.

Scientific Applications:

• Clinical Sequence Coverage Assessment: Supports clinical evaluation of low coverage regions in sequencing data at base-pair resolution.
• Targeted Coverage Analysis: Enables coverage analysis using target files or specified gene names for focused genomic regions.

Methodology:

The tool implements graphical and statistical methods through three analysis modules: Coverage analysis, allele frequency calculation, and binomial distribution analysis.