wpm

wpm generates well plate maps for experimental design by randomizing samples across multiple well plates to control batch effects and plate effects.

Key Features:

• Sample Randomization: Randomizes samples over multiple well plates to reduce plate effects and improve batch effect handling.
• Spatial Constrained Placement: Places samples at random while respecting specific spatial constraints using a backtracking-inspired algorithm.
• Dual Interface Support: Provides both shiny application and command-line/script functions for generating well plate maps.

Scientific Applications:

• Experimental Design: Generates well plate maps for carrying out experiments with improved control of batch effects.
• Plate Effect Control: Reduces plate effects in multi-well plate experiments through strategic sample randomization.

Methodology:

The sample placement algorithm is inspired by the backtracking algorithm, placing samples at random while respecting specific spatial constraints.