Bioconductor

Bioconductor provides extensible R-based software for computational biology and bioinformatics to analyze high-throughput genomic data and support reproducible research.


Key Features:

  • R-based infrastructure: Leverages the R programming language to implement extensible packages and data structures for bioinformatics analyses.
  • High-throughput genomic data analysis: Includes tools explicitly targeted at processing and analyzing high-throughput genomic datasets.
  • Computational biology methods: Provides algorithms and software components for computational biology and bioinformatics tasks.
  • Collaborative development: Encourages contributions from researchers to develop and maintain interoperable packages.
  • Reproducible research: Promotes reproducible research practices to enable independent verification of results.

Scientific Applications:

  • Genomic data analysis: Applied to analysis and interpretation of high-throughput genomic datasets in genomics research.
  • Computational biology research: Supports interdisciplinary computational biology and bioinformatics investigations.
  • Method distribution and reuse: Facilitates dissemination and reuse of analytical methods for genomic studies.

Methodology:

Leverages the R programming language to develop extensible software packages for computational biology and bioinformatics focused on analysis of high-throughput genomic data and on enabling reproducible research.

Topics

Collections

Details

Tool Type:
workflow
Operating Systems:
Linux, Windows, Mac
Programming Languages:
R
Added:
1/17/2017
Last Updated:
12/18/2018

Operations

Publications

Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J. Bioconductor: open software development for computational biology and bioinformatics. Genome Biology. 2004;5(10). doi:10.1186/gb-2004-5-10-r80. PMID:15461798. PMCID:PMC545600.

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M. Orchestrating high-throughput genomic analysis with Bioconductor. Nature Methods. 2015;12(2):115-121. doi:10.1038/nmeth.3252. PMID:25633503. PMCID:PMC4509590.

Documentation