The BioGRID Interaction Database

The BioGRID Interaction Database curates and provides experimentally determined genetic and protein interactions from model organisms and humans to support analysis of molecular interaction networks and pathway conservation.

Key Features:

• Dataset size: 347,966 interactions comprising 170,162 genetic interactions and 177,804 protein interactions curated from over 23,000 publications.
• Species coverage: Complete literature curation for Saccharomyces cerevisiae, Schizosaccharomyces pombe, and Arabidopsis thaliana with expanding curation of multiple metazoan species.
• Human interactions: 48,831 human protein interactions curated from 10,247 publications.
• Automated curation management: An Interaction Management System (IMS) prioritizes, coordinates, and tracks curation activities across international sites and projects.
• Targeted curation initiatives: Focused projects to reveal conserved networks and pathways relevant to human health.
• Data formats: Supports data representation in formats including PSI MI XML.

Scientific Applications:

• Network and pathway analysis: Use curated interactions to reconstruct and analyze molecular interaction networks and pathways.
• Comparative interactomics: Identify conserved interaction networks across model organisms and humans.
• Database integration: Integration of interaction data with model organism databases, Entrez-Gene, and interaction meta-databases for downstream analyses.
• Literature-based curation: Extract experimentally supported genetic and protein interactions from primary literature for hypothesis generation and validation.

Methodology:

An automated Interaction Management System (IMS) is used to prioritize, coordinate, and track literature curation activities across international sites and projects.