BioMThermDB

BioMThermDB provides a curated database of thermophysical and dynamic properties of proteins and their aqueous solutions extracted from scientific literature for comparative analysis and model validation.

Key Features:

• Hydrodynamic radius: Reports hydrodynamic radius measurements for proteins in aqueous solution as reported in source publications.
• Electrophoretic mobility: Contains electrophoretic mobility values measured for protein solutions under documented conditions.
• Zeta potential: Includes zeta potential measurements associated with protein samples and solution conditions.
• Self-diffusion coefficient: Provides self-diffusion coefficient data for proteins in solution extracted from literature reports.
• Solution viscosity: Records solution viscosity values for protein-containing aqueous solutions as reported experimentally.
• Cloud-point temperature: Catalogs cloud-point temperature measurements for protein solutions from the literature.
• Experimental conditions and methods: Associates each measurement with the experimental conditions and the experimental methods employed reported in the source.
• Literature-derived curation: Compiles and curates quantitative measurements and contextual metadata extracted from scientific publications.

Scientific Applications:

• Meta-analysis: Enables meta-analyses of thermophysical and dynamic protein properties across multiple studies.
• Data trend visualization: Supports visualization and comparison of property trends across proteins and solution conditions.
• Comparative analysis: Facilitates comparative analyses between different proteins and their aqueous solutions using standardized reported metrics.
• Model validation: Provides experimental data for validating theoretical and computational models of protein behavior in solution.

Methodology:

Data are extracted from scientific literature and compiled with associated experimental conditions and the experimental methods reported in the source publications.