BiQ Analyzer

BiQ Analyzer performs visualization and quality control of DNA methylation data derived from bisulfite sequencing to support analysis and interpretation of methylation results.

Key Features:

• End-to-End Support: Imports sequence files from sequencing machines and generates publication-quality diagrams.
• Sequence Alignment and Editing: Aligns bisulfite-converted sequences and allows exclusion or correction of problematic sequences.
• Quality Control: Automatically assesses data quality and issues warnings and suggestions for handling problematic sequences.
• Statistical Analysis: Performs basic statistical analyses on methylation data.

Scientific Applications:

• Epigenetic research: Analysis of DNA methylation patterns from bisulfite sequencing datasets.
• Gene regulation studies: Investigation of methylation-associated regulation of gene expression.
• Disease mechanism investigations: Characterization of methylation changes related to disease.
• Developmental biology: Examination of methylation dynamics during development.

Methodology:

The tool is implemented using the Java programming language.