BISQUE

BISQUE performs conversion of molecular identifiers, loci, and variants among database conventions to enable accurate mapping of residues in the human genome, genes, transcripts, and proteins.

Key Features:

• Graph Traversal Algorithm: Employs a graph traversal algorithm to generalize identifier conversion across different classes of molecules.
• Bidirectional Conversion: Supports conversion of identifiers in both directions between source and target database conventions.
• Molecule-Class Generalization: Handles mapping for residues in the human genome, genes, transcripts, and proteins within a unified conversion framework.
• Locus and Variant-Specific Conversion: Performs conversions that are specific to genomic loci and variants to preserve positional and allelic accuracy.

Scientific Applications:

• Genomic Variant Mapping: Enables precise translation of variant and locus identifiers for genomic analyses and interpretation.
• Cross-Database Identifier Harmonization: Facilitates integration of molecular identifiers from multiple database conventions for comparative studies.
• Molecular Data Integration: Supports combining gene, transcript, protein, and residue-level data across resources for downstream bioinformatics analyses.

Methodology:

Uses a graph traversal algorithm to generalize conversions across molecule classes and supports bidirectional mappings among database conventions.