BONEcheck

BONEcheck estimates personalized fracture risk and skeletal age to support prevention and management decisions for osteoporotic fractures.

Key Features:

• Modular Design: Comprises three modules: input data, risk estimates, and risk context.
• Input Data Module: Collects age, gender, prior fracture history, fall incidence, bone mineral density (BMD), comorbidities, and genetic variants associated with BMD.
• Risk Estimation: Calculates the probability of any fragility fracture and hip fracture within five years, estimates subsequent fracture risk, skeletal age, and time until osteoporosis, and presents probabilities numerically and as human icon arrays.
• Risk Contextualization: Contextualizes risk assessments using Australian treatment and management guidelines and quantifies potential fracture risk reduction and survival benefits.
• Skeletal Age Estimation: Estimates skeletal age by combining chronological age with years of life lost due to fractures or exposure to mortality-elevating risk factors.
• Data Sources: Developed using datasets from the Dubbo Osteoporosis Epidemiology Study and the Danish Nationwide Registry.

Scientific Applications:

• Shared decision-making: Enables healthcare professionals and patients to discuss bone health management using personalized risk profiles.
• Early risk identification: Supports early identification of high-risk individuals to facilitate targeted interventions that mitigate fracture risk.
• Guideline-aligned clinical assessment: Provides risk information aligned with established osteoporosis care guidelines to inform treatment decisions.

Methodology:

Collects specified input variables (age, gender, prior fracture history, fall incidence, BMD, comorbidities, genetic variants associated with BMD); calculates five-year probabilities for any fragility fracture and hip fracture, subsequent fracture risk, skeletal age, and time until osteoporosis; presents probabilities numerically and as human icon arrays; contextualizes results using Australian treatment and management guidelines and estimates potential fracture risk reduction and survival benefits; estimates skeletal age by combining chronological age with years of life lost due to fractures or exposure to mortality-elevating risk factors; developed using the Dubbo Osteoporosis Epidemiology Study and the Danish Nationwide Registry.