BpForms

BpForms represents the molecular structures of DNA, RNA, and proteins, including non-canonical residues, caps, crosslinks, nicks, and circular topologies, to enable precise description of macromolecular primary structure for integration and modeling.

Key Features:

• Detailed Molecular Descriptions: BpForms encodes both canonical and non-canonical monomeric units and captures crosslinks, nicks, caps, and circular topologies in DNA, RNA, and proteins.
• Integration Across Omics: BpForms provides a standardized format that facilitates integration of macromolecular structural information across epigenomics, transcriptomics, and proteomics for systems biology and synthetic biology.
• Support for Non-Canonical Modifications: BpForms represents non-canonical residues, caps, crosslinks, and nicks to enable accurate representation of modified macromolecules.
• Enhanced Collaboration and Model Development: BpForms enables consistent quality control and information exchange to support collaborative development of whole-cell computational models.

Scientific Applications:

• Quality Control in Omics Research: Standardizing representation of complex molecular structures to assist rigorous quality control of omics data.
• Systems Biology Modeling: Enabling assembly of global models that incorporate post-translational modifications and other non-canonical interactions.
• Bioengineering Design: Providing structural representations to support design of cells with expanded genetic codes and synthetic parts.

Methodology:

BpForms employs a structured approach to represent macromolecules as combinations of their fundamental structural components.