BrainWiki

BrainWiki enables direct comparison and integration of human and mouse brain anatomy, molecular profiles from single-cell transcriptomics and epigenetic profiling, and connectivity data from diffusion MRI to support comparative neuroanatomy and translational studies including mapping to transgenic mouse models.

Key Features:

• Comparative anatomical integration: Direct mapping and comparison of human and mouse brain regions to facilitate cross-species anatomical correspondence and translation to transgenic mouse models.
• Multimodal molecular datasets: Incorporation of single-cell transcriptomics and epigenetic profiling to provide region- and cell-type-resolved gene expression profiles.
• Connectivity data: Inclusion of diffusion MRI–derived connectivity information within brain atlases to represent structural connectivity and neural circuitry.
• Brain atlases: Compilation of comprehensive atlases detailing gene expression, connectivity, and cell types across human and mouse brains.
• Cell-type annotation: Representation of neuronal cell types and associated cell-type specific data within anatomical regions.
• Region-associated literature references: Association of brain regions with published articles and literature references to link anatomical and molecular data to existing studies.

Scientific Applications:

• Comparative neuroanatomy: Mapping homologous structures and differences between human and mouse brains for basic anatomical studies.
• Translational research: Translating findings from transgenic mouse models to human neurobiology using integrated anatomical and molecular data.
• Cell-type and molecular profiling: Characterizing neuronal and non-neuronal cell types and their gene expression patterns via single-cell transcriptomics and epigenetic data.
• Connectivity and circuitry analysis: Investigating structural connectivity and neural circuitry using diffusion MRI–based connectivity integrated with atlas information.
• Pathology and function correlation: Linking region-specific gene expression, cell types, and connectivity to brain function and pathology through integrated datasets and literature.

Methodology:

Integration of human and mouse anatomical data with single-cell transcriptomics, epigenetic profiling, and diffusion MRI to produce brain atlases and region-associated literature mappings.