BreakTrans

BreakTrans maps predicted gene fusions to their corresponding genomic structural rearrangements to validate fusion predictions and characterize rearrangement events.

Key Features:

• Validation of Predictions: Associates predicted gene fusions with specific genomic structural rearrangements to confirm fusion events.
• Discovery of Novel Events: Identifies previously unrecognized gene fusion events by linking fusion predictions to structural alterations.
• Mechanistic Interpretation: Links gene fusions to structural rearrangements to provide mechanistic insights into how rearrangements generate fusion transcripts.

Scientific Applications:

• Cancer Research and Diagnosis: Detects gene fusions and their originating genomic alterations to inform personalized cancer research and targeted therapy development.
• Tumor Evolution Studies: Elucidates relationships between structural rearrangements and oncogenic processes to support studies of tumor evolution.

Methodology:

Computationally correlates predicted gene fusions with structural rearrangements through analysis of genomic data and has been applied to validate known fusions and discover novel ones in breast cancer cell lines.