Bubastis

Bubastis identifies logical changes between ontology versions and maps ontology views to support consistent annotation of biological sample variables across cross-domain experiments such as gene expression studies.

Key Features:

• Ontology Comparison: Analyzes pairs of ontologies—often successive versions of the same ontology—to detect and present logical modifications between them.
• Cross-Domain Application Support: Supports ontologies that represent variables across diverse experimental domains, including gene expression datasets spanning multiple domains.
• Ontology Mapping and Views: Creates ontology mappings and tailored ontology views to integrate multiple ontologies into coherent, application-relevant representations.
• Change Detection: Employs algorithms to detect logical changes within ontologies to inform annotation updates and version tracking.

Scientific Applications:

• Cross-domain gene expression analysis: Enables consistent representation and comparison of sample variables across gene expression studies spanning different domains.
• Annotation maintenance and ontology versioning: Supports tracking of ontology changes to maintain up-to-date biological annotations.
• Genomics and proteomics data integration: Facilitates integration of diverse ontological resources for comprehensive investigations in genomics and proteomics.

Methodology:

Uses ontology mapping tools, ontology view creation, and change detection algorithms.