C2CDB

C2CDB integrates comprehensive information and analysis tools for cancer-related circular RNAs (circRNAs), encompassing expression data, biological traits, and molecular mechanisms across 30 cancer types.

Key Features:

• CircRNA Repository: Contains 318,158 cancer-related circRNAs expressed in tumors and adjacent tissues across 30 cancer types.
• Molecular Mechanism Annotations: Provides miRNA binding, RNA-binding protein interaction, coding potential, base modification, mutation, and secondary structure information.
• Literature Compilation: Collects published literature on cancer circRNAs with extracted content on biological functions, mechanisms, and molecular tools.
• Integrated Analysis Tools: Offers tools to analyze circRNA-miRNA ceRNA interaction, circRNA encoding, and circRNA biogenesis.
• Nomenclature Curation: Curates and integrates chaotic circRNA nomenclature to address confusion and ambiguity in designations.

Scientific Applications:

• Cancer circRNA Research: Enables investigation of circRNA roles in tumorigenesis through comprehensive expression and mechanistic data.
• Competing Endogenous RNA Analysis: Supports analysis of circRNA-miRNA ceRNA interaction networks in cancer contexts.
• CircRNA Biogenesis Studies: Facilitates investigation of circRNA formation mechanisms through dedicated analysis tools.
• CircRNA Translation Potential: Assesses circRNA coding potential to explore possible peptide-encoding functions.

Methodology:

C2CDB extracts and presents pivotal content from published literature encompassing biological functions, underlying mechanisms, and molecular tools.