CADgene

CADgene catalogs published genetic association data and functional annotations for coronary artery disease to support genetic research.

Key Features:

• Extensive Gene Repository: Contains over 300 candidate genes associated with CAD derived from more than 1,300 publications.
• Functional Categorization: Classifies candidate genes into 12 functional categories based on roles relevant to coronary artery disease.
• Detailed Annotations: Provides general gene information, Gene Ontology (GO) annotations, KEGG pathways, and protein-protein interactions for each gene.
• Study-Specific Data: Includes case-control study sizes, population details, single nucleotide polymorphisms (SNPs), odds ratios, and P-values.
• Cumulative GWAS Data: Integrates data from 11 publications reporting CAD genome-wide association study findings.

Scientific Applications:

• Genetic marker identification: Facilitate identification and validation of SNPs and gene associations implicated in coronary artery disease.
• Functional interpretation: Support exploration of gene functions and protein-protein interactions within CAD-relevant pathways using GO and KEGG annotations.
• Meta-analysis and replication: Enable meta-analyses and replication studies by providing aggregated study-specific metrics such as odds ratios and P-values.
• Hypothesis generation: Provide a consolidated source of candidate genes and annotations to inform experimental and computational hypotheses in cardiovascular genetics.

Methodology:

Curated and integrated genetic association and annotation data from over 1,300 publications, including aggregation of results from 11 CAD GWAS publications.