caffsim

caffsim simulates plasma caffeine concentrations using a population pharmacokinetic model to predict exposure and potential intoxication in children, adolescents, and young adults.

Key Features:

• Population Pharmacokinetic Model: Utilizes an established population pharmacokinetic model to simulate caffeine metabolism and disposition across different populations.
• R Implementation: Implemented as an R package for performing pharmacokinetic simulations of caffeine.
• Single and Multiple Ingestions: Simulates plasma concentration–time profiles following single or multiple ingestions.
• Predictive Outputs and Visualization: Calculates and visualizes plasma caffeine concentrations and assesses how long potentially toxic concentrations may persist.

Scientific Applications:

• Toxicity Prediction: Predicts when plasma caffeine levels may reach toxic concentrations, particularly in sensitive groups.
• Clinical Evaluation: Assists evaluation of the relationship between caffeine intake and acute symptoms of toxicity.
• Educational Use: Supports teaching and understanding of caffeine pharmacokinetics across different populations.

Methodology:

Uses a previously established population-pharmacokinetic model to simulate changes in plasma caffeine concentration over time after single or multiple ingestions, enabling assessment of duration of toxic concentrations.