The Ca2+ genome database

The Ca2+ genome database maps genes involved in calcium (Ca2+) signaling pathways and links them to human genetic disorders to support analysis of Ca2+-related molecular mechanisms.

Key Features:

• Extensive Gene Mapping: Identifies 1805 genes that act as regulators or targets within intracellular Ca2+ signaling pathways, curated using Gene Ontology terms and genome databases.
• Linkage to Genetic Disorders: Associates the 1805 Ca2+ genes with 1470 human genetic disorders and reported mutations within Ca2+ genes.
• Network Analysis: Reveals a network with scale-free properties when mapping Ca2+ genes to their associated genetic disorders.

Scientific Applications:

• Gene Function Studies: Enables investigation of specific roles of genes within Ca2+ signaling pathways.
• Genetic Disorder Research: Supports identification of genetic underpinnings of diseases by providing gene–disease associations and mutation data for Ca2+ genes.
• Network Biology: Allows analysis of scale-free network topology to examine robustness, vulnerability, and hub genes in Ca2+ signaling–disease networks.

Methodology:

Uses Gene Ontology terms and genome databases to identify and categorize genes involved in Ca2+ signaling and associates them with human genetic disorders.