CAIC
CAIC performs phylogenetically informed comparative analyses using independent contrasts to test hypotheses about trait evolution among species.
Key Features:
- Independent Contrasts: Implements the independent contrasts algorithm to partition variance among species into independent linear contrasts at nodes of a species tree.
- Phylogenetic Information: Uses phylogenetic information from the dataset's species tree to account for shared evolutionary history in statistical comparisons.
- Partitioning Procedures: Provides two partitioning procedures, one for datasets where all variables are continuous and another for datasets that include a discrete variable.
- Non-independence Correction: Accounts for non-independence among species due to common descent, addressing the failure of standard regression assumptions in comparative data.
- Correlated Evolution Testing: Enables testing hypotheses about correlated evolution among traits across species.
- Parameter Estimation: Supports estimation of parameters such as allometric exponents.
- Rate Comparisons: Allows comparison of rates of evolutionary change across species.
Scientific Applications:
- Comparative Multi-species Analysis: Analysis of comparative multi-species datasets involving continuous variables to test evolutionary hypotheses.
- Adaptation Hypothesis Testing: Testing hypotheses about organism adaptation to environments through species comparisons while accounting for phylogeny.
- Trait Correlation Studies: Assessing correlated evolution among morphological or physiological traits.
- Allometry Studies: Estimating allometric exponents to study scaling relationships among traits.
- Evolutionary Rate Analysis: Comparing rates of evolutionary change across lineages within a phylogenetic framework.
Methodology:
Computes independent linear contrasts from a species tree and partitions variance at phylogenetic nodes, with two procedures for entirely continuous datasets and for datasets that include a discrete variable.
Topics
Details
- Tool Type:
- command-line tool
- Operating Systems:
- Mac
- Added:
- 8/3/2017
- Last Updated:
- 11/25/2024
Operations
Publications
Purvis A, Rambaut A. Comparative analysis by independent contrasts (CAIC): an Apple Macintosh application for analysing comparative data. Bioinformatics. 1995;11(3):247-251. doi:10.1093/bioinformatics/11.3.247. PMID:7583692.
PMID: 7583692