CalliCog

CalliCog provides an open-source, scalable in-cage platform for automated cognitive testing and simultaneous neural recordings with freely behaving nonhuman primates, specifically common marmosets (Callithrix jacchus).

Key Features:

• Modular Operant Chambers: Autonomous operant chambers integrate seamlessly with home cages to eliminate human intervention during experiments.
• Touchscreen-Based Cognitive Tasks: Enables training of experimentally naive marmosets in touchscreen-based cognitive tasks with proficiency achieved within 2 weeks.
• Behavioral-Neural Synchronization: Enables precise synchronization of behavioral data with electrocorticography (ECoG) recordings from freely moving animals.
• Cross-Facility Reproducibility: Validated across two independent facilities for training and task completion.

Scientific Applications:

• Behavioral Flexibility Research: Supports tasks probing behavioral flexibility in freely behaving marmosets.
• Working Memory Studies: Supports tasks probing working memory in freely behaving marmosets.
• Electrocorticography Research: Enables neurobehavioral research combining cognitive testing with ECoG recordings in freely moving nonhuman primates.
• Translational Neuroscience: Facilitates cognitive experimentation to narrow the translational gap between preclinical models and human cognition.

Methodology:

CalliCog employs modular operant chambers that operate autonomously and integrate with home cages, with precise synchronization of behavioral data and electrocorticography (ECoG) recordings.