cancercelllines.org

cancercelllines.org curates and integrates genomic profiling data, somatic mutation information, and associated metadata for thousands of human cancer cell lines from multiple primary resources, enabling access to copy number and single nucleotide variant data mapped to the GRCh38 reference genome.

Key Features:

• Copy Number Profile Collection: The resource contains over 5600 copy number profiles gathered from multiple sources.
• Single Nucleotide Variant Annotations: The resource provides single nucleotide variant annotations for 16000 cell lines.
• GRCh38 Reference Genome Mapping: All genomic data are provided with mappings to the GRCh38 reference genome.
• GA4GH Beacon v2 API: Both genomic variations and associated curated metadata can be queried through the GA4GH Beacon v2 Application Programming Interface.
• GA4GH Data Schemas: Extensive data retrieval is enabled using GA4GH data schemas.

Scientific Applications:

• Cancer Cell Line Genomic Research: The resource supports studies of genomic alterations in cancer cell lines as models for oncogenetic events.
• Pharmaceutical Development and Testing: The resource enables research supporting the development and testing of pharmaceuticals using cancer cell line models.
• Cellular Mechanism Studies: The resource facilitates studies of cellular mechanisms in cancer biology.

Methodology:

Data were curated from a variety of primary resources and integrated to combine copy number and single nucleotide variants data.