CancerInSilico

CancerInSilico simulates tumor progression using mathematical models implemented in C++ with an R interface for generating outputs and analyzing high-throughput genomic data.


Key Features:

  • Mathematical Modeling: Enables simulation of complex tumor progression and tumor dynamics using mathematical frameworks.
  • C++ Implementation: Implements core models in C++ to provide computational performance for large-scale genomics simulations.
  • R Interface: Exposes model outputs to R for output generation and analysis of high-throughput genomic data using R libraries.

Scientific Applications:

  • Oncology Research: Supports investigation of cancer development and progression through in silico simulations.
  • Hypothesis Testing: Enables testing of mechanistic hypotheses about tumor biology and dynamics.
  • Therapeutic Strategy Development: Facilitates exploration of interventions and the development of new therapeutic strategies via simulated scenarios.

Methodology:

Mathematical models are implemented in C++ and coupled with R-based analysis to simulate tumor biology and analyze high-throughput genomic data.

Topics

Collections

Details

License:
GPL-2.0
Tool Type:
command-line tool, library
Operating Systems:
Linux, Windows, Mac
Programming Languages:
R
Added:
1/17/2017
Last Updated:
11/25/2024

Operations

Publications

Huber W, Carey VJ, Gentleman R, Anders S, Carlson M, Carvalho BS, Bravo HC, Davis S, Gatto L, Girke T, Gottardo R, Hahne F, Hansen KD, Irizarry RA, Lawrence M, Love MI, MacDonald J, Obenchain V, Oleś AK, Pagès H, Reyes A, Shannon P, Smyth GK, Tenenbaum D, Waldron L, Morgan M. Orchestrating high-throughput genomic analysis with Bioconductor. Nature Methods. 2015;12(2):115-121. doi:10.1038/nmeth.3252. PMID:25633503. PMCID:PMC4509590.

Documentation

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