CancerPPD

CancerPPD provides a curated repository of experimentally verified anticancer peptides (ACPs) and anticancer proteins to support peptide-based cancer therapeutic research.

Key Features:

• Content scope: Contains 3,491 anticancer peptide (ACP) entries and 121 anticancer protein entries.
• Molecule types: Includes both anticancer peptides (natural and non-natural) and anticancer proteins.
• Data provenance: Data are curated from published research articles, patents, and other databases.
• Annotation details: Entries provide source of origin, nature, and specific anticancer activities for each peptide or protein.
• Chemical modifications: Documents N- and C-terminal modifications, non-natural residues, chemically modified components, and D-amino acids.
• Structural data: Stores predicted tertiary structures generated with PEPstr, reports conformational details, and includes secondary structure assignments by DSSP.
• Biological coverage: Contains experimental data across approximately 249 cancer cell lines and 16 distinct assays.

Scientific Applications:

• Comparative efficacy analysis: Evaluation of ACP activity across approximately 249 cancer cell lines and 16 assay types.
• Structure-guided peptide design: Use of PEPstr-predicted tertiary structures and DSSP-assigned secondary states to inform design of novel anticancer peptides.
• Modification impact studies: Investigation of how N-/C-terminal modifications, non-natural residues, chemical modifications, and D-amino acids affect anticancer activity.
• Candidate selection for validation: Identification and prioritization of peptides and proteins for experimental validation or therapeutic development.

Methodology:

Tertiary structures were predicted using PEPstr and secondary structure states were assigned with DSSP.