CAST-HSROC

CAST-HSROC computes summary points from the hierarchical summary Receiver Operating Characteristic (HSROC) model to estimate sensitivity or specificity and their 95% credible intervals for diagnostic test accuracy research.

Key Features:

• Calculation of summary points: Computes point estimates and 95% credible intervals (CrIs) for sensitivity or specificity conditional on a fixed value of the complementary parameter using the HSROC model.
• Support for Summary of Findings (SoF) tables: Produces summary statistics intended for use in Summary of Findings tables to assess the certainty of evidence from HSROC analyses.
• Convergence check recommendation: Requires verification of HSROC model convergence before interpreting point estimates and credible intervals to ensure result reliability.

Scientific Applications:

• Systematic reviews: Provides summary estimates from HSROC models for inclusion in diagnostic test accuracy systematic reviews.
• Guideline development: Supplies point estimates and CrIs for sensitivity or specificity to inform guideline evidence profiles and recommendations.
• Diagnostic test evaluation: Enables quantitative assessment of diagnostic test performance by summarizing sensitivity-specificity trade-offs across studies.

Methodology:

Uses the hierarchical summary ROC (HSROC) model to derive summary statistics and to calculate point estimates with 95% credible intervals for sensitivity or specificity at fixed values of the complementary parameter; model convergence should be checked.