CCancer

CCancer provides gene list enrichment analysis by intersecting input gene lists with a curated database of experimentally derived gene lists to identify significant overlaps and co-reported gene pairs.

Key Features:

• Extensive database coverage: CCancer contains 3,369 gene lists extracted from 2,644 peer-reviewed papers spanning approximately 80 journals.
• Enrichment analysis: It performs enrichment analysis by intersecting an input gene list with the database to report studies with significant overlaps.
• Gene pair co-occurrence reporting: It reports gene pairs from the input list that are frequently co-reported in other studies.
• Automated literature aggregation and curation: The database is populated via automated collection and curation of gene lists from experimental and clinical studies.

Scientific Applications:

• Study retrieval: Identify published studies reporting gene lists similar to a query list to support literature review and meta-analysis.
• Interaction discovery: Discover potential genetic interactions by examining frequently co-reported gene pairs.
• Functional inference: Infer functional roles of genes within biological pathways or clinical conditions by comparing with reported experimental gene lists.

Methodology:

Automated collection and curation of gene lists from experimental and clinical peer-reviewed publications and implementation of enrichment analysis that compares input gene lists against the database to highlight significant intersections and co-occurrences.