CCDB

CCDB provides a curated database of 537 experimentally validated genes and altered microRNAs implicated in cervical cancer, with sequence, exon-intron, chromosomal, functional, interaction, homology annotations and links to external databases to support genomic and comparative analyses.

Key Features:

• Curated Gene Catalog: Contains 537 genes associated with cervical cancer processes including methylation, gene amplification, mutation, polymorphism, and changes in expression levels, with associations supported by literature references.
• Detailed Gene Information: Provides exon-intron structure, chromosomal location, functional annotations, mRNA, CDS and protein sequence information, and ontological classifications for each gene.
• Interacting Partners and Homology: Includes data on interacting partners and homologous genes in other eukaryotic genomes to facilitate comparative and functional analyses.
• Integration with External Databases: Links gene and microRNA entries to various public databases to expand available related information.
• MicroRNA Data: Documents microRNAs altered in cervical cancer alongside protein-coding gene entries.
• Sequence Similarity Search Tool: Provides an online sequence similarity search capability to identify homologous sequences across species.

Scientific Applications:

• Genomic Studies: Use validated gene and sequence data for analyses of genomic alterations in cervical cancer.
• Functional Genomics: Use functional annotations, ontologies, and interaction data to investigate gene function and pathways in cervical carcinogenesis.
• Comparative Genomics: Use homologous gene data and sequence similarity searches for cross-species and eukaryotic comparative analyses.
• Therapeutic Target Identification and Hypothesis Testing: Support identification of candidate therapeutic targets and biomarkers and enable hypothesis generation and testing in cervical carcinogenesis.

Methodology:

Provides an online sequence similarity search tool and links entries to external public databases.