ccmap

ccmap identifies drugs and drug combinations that reverse or mimic gene expression signatures to support drug repurposing and combination-therapy research.

Key Features:

• Gene Expression Signature Analysis: ccmap analyzes gene expression data to predict how individual drugs and drug combinations alter transcriptional signatures.
• Drug Repurposing Potential: ccmap identifies compounds whose induced expression changes oppose or mimic disease-associated signatures to generate repurposing hypotheses.
• Combination Therapy Exploration: ccmap evaluates and ranks drug combinations for their combined effects on gene expression signatures.

Scientific Applications:

• Disease Reversal and Mimicry: Identification of therapeutic strategies that reverse disease-associated transcriptional states or mimic healthy gene expression profiles.
• Drug Repurposing and Combination Therapy Research: Prioritization of existing compounds and combinations for follow-up experimental validation in drug-repurposing studies.

Methodology:

Operates within the Bioconductor ecosystem using the R programming language and interoperable Bioconductor packages.