CDR-Finder

CDR-Finder identifies centromeric hypomethylated regions from long-read sequencing data in high-quality, contiguous genome assemblies.

Key Features:

• CDR Detection: Identifies Centromere Dip Regions (CDRs) in both large and short centromeres.
• BED File Output: Generates BED files indicating the location of CDRs within centromeres for downstream analysis.
• Visualization: Outputs plots for visualization and validation of identified CDRs.

Scientific Applications:

• Centromere Annotation: Identifies regions of hypomethylation within centromeres associated with CENP-A-containing chromatin that marks kinetochore location.
• Epigenetic Analysis: Enables investigation of complex centromeric regions at the sequence and epigenetic levels using long-read sequencing data.

Methodology:

CDR-Finder analyzes long-read sequencing data to identify hypomethylated regions within centromeres of assembled genomes.