CellCollective

CellCollective enables collaborative construction, simulation, and analysis of large-scale models of biochemical networks to study cellular processes and perturbation experiments.

Key Features:

• Collaborative model construction and curation: Enables collaborative assembly and curation of large-scale models of biological processes and biochemical networks.
• Real-time simulation: Performs real-time simulation and analysis of biochemical pathways.
• Perturbation experiments: Simulates loss-of-function and gain-of-function experiments and other perturbations on models.
• Dynamic hypothesis testing: Supports dynamic testing of "what-if" hypotheses on models.
• Non-mathematical modeling: Allows model construction and analysis without requiring mathematical equations or computer code.

Scientific Applications:

• Modeling cellular complexity: Enables study of cellular complexity and the behavior of interconnected biochemical networks.
• Biochemical pathway analysis: Facilitates analysis and simulation of biochemical pathways.
• Signal transduction studies: Supports modeling and investigation of signal transduction pathways.
• Perturbation outcome prediction: Predicts consequences of loss/gain of function perturbations on cellular behavior.
• Hypothesis exploration: Enables exploration of "what-if" hypotheses to investigate system-level responses.

Methodology:

Construction and curation of large-scale models; real-time simulation and analysis of biochemical pathways; simulation of loss- and gain-of-function perturbations; and dynamic "what-if" hypothesis testing without requiring mathematical equations or computer code.