CellCraft

CellCraft streamlines gene regulatory network inference from single-cell RNA sequencing data by integrating multiple GRN reconstruction tools within a unified web application.

Key Features:

• Visual Programming Interface: Simplifies the design and execution of complex multistep analyses for GRN inference.
• Integration of GRN Reconstruction Tools: Incorporates multiple GRN reconstruction tools, including TENET, within a unified framework.
• Modular Plugin Architecture: Enables extensibility for the incorporation of newly developed single-cell analysis algorithms.

Scientific Applications:

• Gene Regulatory Network Inference: Reconstructs GRNs from single-cell RNA sequencing data to understand cellular dynamics at the molecular level.
• Integrative scRNA-seq Analysis: Facilitates integrative GRN analysis of single-cell RNA sequencing datasets through combined use of multiple reconstruction methods.

Methodology:

CellCraft employs a visual programming approach to connect and execute multiple GRN reconstruction tools, including TENET, in configurable multistep workflows.