CellMap

CellMap visualizes protein-protein interaction (PPI) networks mapped to subcellular localization to contextualize PPIs within specific cellular compartments.

Key Features:

• Subcellular localization contextualization: Maps PPI networks onto defined subcellular locations to indicate where interactions occur within the cell.
• User-defined areas of interest: Accepts uploaded cell images and allows definition of regions to display PPIs relative to those regions.
• Customizable visualization: Uses a default cartoon cell representation with the ability to replace or modify the representation for alternate cellular models.
• Annotation integration: Supports subcellular localization annotations provided by users or sourced from an in-house database.

Scientific Applications:

• Enhanced understanding of cellular processes: Visualizing PPIs within subcellular compartments aids interpretation of spatially regulated molecular interactions involved in cellular functions.
• Hypothesis generation and testing: Region-specific mapping and annotation integration enable formulation and evaluation of hypotheses about protein roles in particular compartments.
• Integration with experimental data: Overlaying PPI networks onto cell images facilitates alignment of computational interaction data with microscopy or imaging observations.

Methodology:

Implemented in JavaScript.