CellPalmSeq

CellPalmSeq catalogs RNA sequencing expression patterns of palmitoylating and depalmitoylating enzymes across human single-cell types, bulk tissues, cancer cell lines, and common non-human laboratory cell lines to support analysis of protein S-palmitoylation regulation.

Key Features:

• Curated RNAseq Data: Compiles RNA sequencing data to map expression profiles of genes involved in palmitoylation processes.
• Integrated multi-source compilation: Aggregates RNAseq datasets from multiple sources to produce a unified collection of expression data.
• Focus on palmitoylation machinery: Specifically annotates palmitoylating and depalmitoylating enzymes and their expression patterns relevant to protein S-palmitoylation.
• Comprehensive sample coverage: Includes single-cell types, bulk tissues, cancer cell lines, and non-human laboratory cell lines for broad comparative analyses.

Scientific Applications:

• Disease research: Enables investigation of dysregulated S-palmitoylation in conditions such as brain disorders, metabolic diseases, viral infections, and cancer by providing expression context for palmitoylation-regulating genes.
• Cell line selection: Provides expression data to inform selection of appropriate human and non-human laboratory cell lines for experimental studies of palmitoylation-dependent processes.
• Insights into cellular physiology: Reveals diverse expression patterns of palmitoylation-regulating genes to support mechanistic studies of protein localization, function, and interactions.

Methodology:

CellPalmSeq was developed by integrating RNAseq data from multiple sources to create a comprehensive database of expression profiles for palmitoylating and depalmitoylating enzymes.