CellRemorph

CellRemorph converts and manipulates astrocyte morphologies in Blender to enable simulation and analysis of astrocyte structure and function.


Key Features:

  • Transformation Capabilities: Converts polygonal surface meshes to adjustable surface point clouds and vice versa to provide alternative morphology representations for analysis and simulation.
  • Selection Precision: Enables precise selection and extraction of nanoprocesses within astrocyte structures for targeted morphological analysis.
  • Segmentation Functionality: Slices morphologies into segments with equal surface areas or equal volumes to create uniform sections for comparative studies.

Scientific Applications:

  • Computational modeling of astrocyte morphology: Builds models that capture intricate morphological details of astrocytes from existing morphological data.
  • Simulation of astrocyte function: Prepares morphology representations tailored to simulations probing astrocyte roles in health and disease.
  • Comparative morphological analysis: Produces uniformly segmented models to facilitate comparative studies and detailed simulations.
  • Targeted nanoprocess studies: Isolates nanoprocesses for region-specific structural and functional analyses.

Methodology:

Computational steps include conversion between polygonal surface meshes and adjustable surface point clouds, selection and extraction of nanoprocesses, and slicing morphologies into equal surface-area or equal-volume segments.

Topics

Details

License:
GPL-3.0
Cost:
Free of charge
Tool Type:
desktop application
Operating Systems:
Mac, Linux, Windows
Added:
1/1/2024
Last Updated:
11/24/2024

Operations

Publications

Keto L, Manninen T. CellRemorph: A Toolkit for Transforming, Selecting, and Slicing 3D Cell Structures on the Road to Morphologically Detailed Astrocyte Simulations. Neuroinformatics. 2023;21(3):483-500. doi:10.1007/s12021-023-09627-5. PMID:37133688. PMCID:PMC10406679.

PMID: 37133688
Funding: - Academy of Finland: 326494