CGEN

CGEN performs statistical analysis of case-control studies in genetic epidemiology, providing maximum-likelihood estimation for complete data and haplotype-based analysis that accommodates missing phase information.

Key Features:

• Maximum-Likelihood Analysis: Implements maximum-likelihood estimation techniques for analysis of case-control data with complete information.
• Haplotype-based Genetic Analysis: Provides algorithms to analyze haplotypes when phase information is missing.

Scientific Applications:

• Case-control genetic association studies: Estimation and inference of genetic effects in case-control designs.
• Analyses with incomplete phase information: Haplotype-based investigations of genetic variation when phase is unknown.

Methodology:

Maximum-likelihood estimation for case-control data with complete information and computational algorithms for haplotype analysis accommodating missing phase, implemented in R.