Cancer Genome Interpreter (CGI)

Cancer Genome Interpreter interprets and annotates tumor somatic variants from genome sequencing to assess their roles as cancer drivers and their therapeutic relevance.

Key Features:

• Automation: Automates the interpretation of newly sequenced cancer genomes.
• Annotation: Annotates detected tumor alterations and assesses their potential roles as cancer drivers and implications for treatment response.
• Evidence-Based Organization: Organizes results into distinct levels of evidence based on current scientific knowledge to evaluate the significance and therapeutic relevance of each alteration.

Scientific Applications:

• Oncology variant interpretation: Supports interpretation of somatic variants in research and clinical oncology by providing evidence-graded annotations.
• Therapeutic target identification: Facilitates identification of therapeutically actionable targets by annotating alterations with varying levels of evidence for treatment response.
• Precision oncology decision support: Helps elucidate potential driver alterations and their impact on treatment efficacy to inform personalized medicine approaches.

Methodology:

Integrates knowledge from multiple resources and computational methods to annotate tumor alterations.