ChagasDB

ChagasDB compiles manually curated molecular data from PubMed to catalogue deregulated molecules observed in hosts infected by Trypanosoma cruzi for research into the molecular basis of Chagas disease.

Key Features:

• Manual Curation: Entries were manually curated from peer-reviewed publications to ensure accurate annotation of reported findings.
• Literature Source: Data were extracted from all publications indexed in PubMed returned by the keyword "Chagas disease".
• Scope of Data: The database records deregulated molecules observed in hosts, including humans, mice, and other mammals, following Trypanosoma cruzi infection.

Scientific Applications:

• Molecular Research: Enables investigation of molecular alterations and pathways involved in Chagas disease pathogenesis.
• Drug Discovery and Development: Supports identification of candidate therapeutic targets by highlighting infection-associated molecular changes.
• Comparative Studies: Facilitates comparative analyses across host species to study host–pathogen interactions and conserved responses.

Methodology:

Systematic manual curation of all PubMed publications retrieved with the keyword "Chagas disease" and extraction of reported molecular deregulations observed in hosts following Trypanosoma cruzi infection.