ChemHub

ChemHub provides a curated knowledgebase of chemicals and their biosynthetic pathways to support selection of target molecules based on chemical function and economic application.

Key Features:

• Extensive Database: Contains over 90,000 chemicals with detailed descriptions of their functions.
• Biosynthesis Information: Includes manually curated biosynthetic pathways derived from more than 600,000 published studies, curated by a team of over 100 contributors over the past decade.
• Algorithmic Support: Implements multiple algorithms to facilitate biosynthetic pathway design and precursor discovery.

Scientific Applications:

• Pathway Design: Supports design of novel biosynthetic pathways by combining curated pathway information with algorithmic analyses.
• Precursor Discovery: Enables discovery of candidate precursors for chemical synthesis using algorithmic exploration of biosynthetic data.
• Target Selection for Economic Applications: Informs selection of chemically and economically viable synthetic targets through functional annotations and pathway context.

Methodology:

Content was compiled via manual extraction and curation of published literature, and the resource implements multiple algorithms for biosynthetic pathway design and precursor discovery.