circBase

circBase provides a centralized database of circular RNAs (circRNAs) consolidating curated circRNA annotations, evidence-based expression data, genomic context, and detection scripts to support research into circRNA biology.

Key Features:

• Data integration: Consolidates merged and unified circRNA datasets from multiple studies across animal species.
• Genomic context: Provides genomic coordinates and contextual annotations for circRNAs.
• Expression evidence: Contains evidence-based expression data supporting circRNA presence across organisms.
• Detection scripts: Provides scripts to identify known and novel circRNAs from RNA-seq and sequencing data.
• Stability and expression patterns: Reports the stability and spatiotemporal expression patterns of numerous circRNAs.

Scientific Applications:

• Biomarker discovery: Supports investigation of circRNAs as potential biomarkers based on their stability and specific expression profiles.
• Functional studies: Provides reference annotations and expression evidence to facilitate studies of circRNA biological roles.
• Genomic contextual analysis: Enables analysis of regulatory mechanisms and potential interactions by supplying genomic context and coordinates.

Methodology:

Curates and unifies circRNA datasets reported across animal species; provides scripts and tools to analyze RNA-seq and sequencing data for identification of known and novel circRNAs.